Interleukins changes in blood of non-ethanol liver damage rats of different sex

Non-alcoholic liver disease is associated with injury, such as steatosis, steatohepatitis, fibrosis and cirrhosis. During their development, inflammation occure organs damage develops by help of cytokines influences. The intensity injury depends on sex. aim the study was to evaluate changes interleukins in blood male female rats hepatosis, hepatitis used overdrinking glucose. Material methods investigation. experiments were performed 60 outbred aged from four monthes (start experiment). Animals divided into five groups – control 1 (6 old animals), 2 (8 glucose (3), 4 (4), 2+2 (5). Determined serum Tumor Necrosis Factor Alpha (TNF-α), Interleukin Beta (IL-1β), (IL-4), 10 (IL-10). Results. In 3, 5 we determined increasing proinflammatory interleukins. When comparing results 3 rats, lower values anti-inflammatory noted a reliably insignificant difference content pro-inflammatory Interleukins not detected between 3.When groups, an increase TNF-α IL-1β, decrease IL-4 IL-10 both males females determing, which depended duration consumption. only decreased, can be regarded destructive processes when consumption stopped. females, see IL-10, may indicate effect or its long-term effect, since did differ. Conclusion. An after months, months use, maintained for cessation use use. males, inflammatory reaction more than females.